Geraldine*

Age

  • 87 years old


History of present illness

  • Alzheimer's disease initially diagnosed/first symptoms ~1 year prior to clinical screening
  • APOE4(-)


Medical history

  • Hypertension
  • Incontinence
  • Postmenopausal
  • Bilateral cataract removal
  • Osteoporosis
  • Hand tremors
  • Syncope


Concomitant medications

  • Risedronate sodium for osteoporosis
  • Multivitamin, fish oil, and vitamin E
  • Low-dose aspirin for cardiac prophylaxis


Clinical exam

  • Baseline Alzheimer’s Disease Assessment Scale–Cognitive subscale (ADAS–Cog) of 31
  • Baseline Mini-Mental State Exam (MMSE) of 22


Management

  • Axona 40 g QD added to existing treatment
Measurement of ADAS–Cog and MMSE
Study visit
ADAS–Coga Change in ADAS–Coga MMSEb
Screening
 29 N/A
 18
Baseline
 31 N/A 22
Day 45
 23 -8
 23
Day 90
 21 -10
 19
Day 104
(after 14 days of no treatment)		 27 -4
 21
aLower scores indicate improvement.
bHigher scores indicate improvement.


Follow-up

  • Improved ADAS–Cog score at day 45, and score continued to improve through day 90

*Based on a real patient. Name has been changed.