Rosemary*
Age
- 78 years old
History of present illness
- Alzheimer's disease initially diagnosed/first symptoms ~8 years prior to clinical screening
- APOE4(-)
Medical history
- Hypercholesterolemia
- Hypertension
- Arthritis
- Orthostatic dizziness
- Sleep difficulty
Concomitant medications
- Simvastatin for hypercholesterolemia
- Glucosamine with chondroitin sulfates for arthritis
- Flaxseed and cod liver oil supplements
Clinical exam
- Baseline Alzheimer’s Disease Assessment Scale–Cognitive subscale (ADAS–Cog) of 31
- Baseline Mini-Mental State Exam (MMSE) of 15
Management
- Axona 40 g QD added to existing treatment
| Study visit |
ADAS–Coga | Change in ADAS–Coga | MMSEb |
|---|---|---|---|
| Screening |
27 | N/A |
16 |
| Baseline |
31 | N/A | 15 |
| Day 45 |
23 | -8 |
15 |
| Day 90 |
20 | -11 |
17 |
| Day 104 (after 14 days of no treatment, per study protocol) |
21 | -10 |
16 |
| aLower scores indicate improvement. bHigher scores indicate improvement. |
|||
Follow-up
- ADAS–Cog score progressively improved at days 45 and 90
- ADAS–Cog score remained improved at the washout visit (day 104)
*Based on a real patient. Name has been changed.
